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FLASH GENE

Symbol

NRP1

contributors: mct/shn - updated : 03-11-2017

HGNC name	neuropilin 1
HGNC id	8004

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in agressive advanced prostate carcinoma and in astrocytoma cell lines,in breast cancer in progression constitutional   deletion     deletion of NRP1 in normal epidermis prevents skin tumour initiation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Transgenic mice, in which both NP1 and NP2 were targeted died in utero at E8.5
	Mice deficient for NP2 but heterozygous for NP1 or deficient for NP1 but heterozygous for NP2 were also embryonic lethal and survived to E10-E10.5
	Morpholino-mediated knockdown of zNRP1 in embryos resulted in vascular defects, most notably impaired circulation in the intersegmental vessels
	Overexpression of Y297A and D320A NRP1 mutations in human umbilical vein endothelial cells reduced high-affinity VEGF binding and migration toward a VEGF gradient, and markedly inhibited VEGF-induced angiogenesis in a coculture cell model