motifs/domains
| two N terminal complement C1r/s homology domain (CUB domain), in large extracellular region (a1a2) |
|
two coagulation factor V/VIII homology |
|
domains (designated b1b2) |
|
two regions of homology with the C1 and C2 domains of coagulation factor F5 |
|
a MAM (meprin, A5 antigen, receptor tyrosine phosphatase mu) domain  |
|
a single transmembrane segment |
|
a GIPC (synectin) binding motif (deletion of the GIPC binding motif prevented transition of KDR through RAB11A vesicles and attenuated signaling) |
|
a short cytoplasmic C terminal tail, with three C-terminal residues which form a PDZ-binding motif that influences NRP1-mediated angiogenesis |
| basic FUNCTION
| plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain |
|
implicated in repulsive axon guidance, angiogenesis, cell survival, control of neuronal migration |
|
contributes to both neuronal and vascular patterning by preferentially relaying SEMA3A signals in peripheral axons and VEGF164 signals in blood vessels |
|
function in signaling SEMA3A-evoked neuronal death through FER in cortical neurons |
|
may be a multiple function protein in breast involved in the induction of local invasiveness of neoplasia and angiogenesis and having direct relevance to the progression of breast cancer |
|
facilitates tumor growth and progression |
|
labile to internalization and lysosomal degradation in response to metabolic stress |
|
playing a role with CHL1 in establishment of proper targeting of specific thalamocortical projections |
|
regulates vascular and neural development and acts as a co-receptor for VEGFRs and plexins |
|
plays a prominent role in regulating ligand-induced PDGFR signalling |
|
essential co-receptor for PDGFR signalling, which |
|
may critically contribute to the formation of blood vessels and other mesenchymal tissues |
|
co-receptor for members of the VEGF (vascular endothelial growth factor) family in endothelial cells |
|
role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRA and via selective mobilization of a novel BCAR1 tyrosine phosphorylation pathway |
|
distinct role of NRP1 in KDR signaling |
|
VEGF164/NRP1 signalling promotes GnRH neuron survival cell-autonomously |
|
NRP1 and NRP2 are receptors for guidance cues of the class 3 semaphorin (SEMA) family and are expressed in partially overlapping patterns in sympathetic neural crest (NC) cells and their progeny |
|
requirement for NRP1 and PLXNA1 in dendrite polarization occurs at a developmental time point after the cells have already extended their basally directed axon |
|
is dispensable for suppression of autoimmunity and maintenance of immune homeostasis, but is required by Treg cells to limit anti-tumour immune responses and to cure established inflammatory colitis |
|
functions as a receptor for SEMA4A on Treg cells, and SEMA4A–NRP1 interaction promotes Treg-cell survival and function |
|
role for NRP1 in modulating Treg-cell stability, survival and function in certain tumour microenvironments |
|
NRP1 and NRP2 are transmembrane glycoproteins that are essential for Neural crest cells (NCCs) migration |
|
SEMA3A, -3C, and -3F, likely with coreceptors NRP1, NRP2, and plexin-A1 and/or -A3, promote migration and possibly other activities of human DCs during innate and adaptive immune responses |
