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FLASH GENE
Symbol CIB1 contributors: mct - updated : 08-10-2018
HGNC name calcium and integrin binding 1 (calmyrin)
HGNC id 16920
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in the oligoasthenozoospermia patients
Susceptibility may be Alzheimer disease
Variant & Polymorphism
Candidate gene
Marker
  • significant correlation between the urine CIB1 and serum pro-BNP levels in patients with acute ischemic heart failure (significantly higher)
  • Therapy target
  • potential molecular target for the development of new therapeutics specific for human disorders whose pathogenesis is linked to MAP3K5-mediated signaling events
  • SystemTypeDisorderPubmed
    cancerreproductivebreast
    is a novel therapeutic target for triple-negative breast cancer
    cardiovascularaquiredheart failure
    new strategy for treating hypertrophic heart disease through inhibition of CIB1 or its interaction with calcineurin
    ANIMAL & CELL MODELS
  • Cib1-deleted mice showed a marked reduction in myocardial hypertrophy, fibrosis, cardiac dysfunction and calcineurin–nuclear factor of activated T cells (NFAT) activity after pressure overload, whereas the degree of physiologic hypertrophy after swimming exercise was not altered
  • Cib1 expression is increased in primary mouse megakaryocytes compared to mononuclear bone marrow cells