Symbol
| CIB1
| contributors: mct - updated : 08-10-2018
|
HGNC name
| calcium and integrin binding 1 (calmyrin)
|
HGNC id
| 16920
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
in the oligoasthenozoospermia patients | |
Susceptibility
|
may be Alzheimer disease |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| significant correlation between the urine CIB1 and serum pro-BNP levels in patients with acute ischemic heart failure (significantly higher) | Therapy target
| potential molecular target for the development of new therapeutics specific for human disorders whose pathogenesis is linked to MAP3K5-mediated signaling events | |
|
|
System | Type | Disorder | Pubmed |
cancer | reproductive | breast | |
is a novel therapeutic target for triple-negative breast cancer | cardiovascular | aquired | heart failure | |
new strategy for treating hypertrophic heart disease through inhibition of CIB1 or its interaction with calcineurin |
| |
| Cib1-deleted mice showed a marked reduction in myocardial hypertrophy, fibrosis, cardiac dysfunction and calcineurin–nuclear factor of activated T cells (NFAT) activity after pressure overload, whereas the degree of physiologic hypertrophy after swimming exercise was not altered | |
Cib1 expression is increased in primary mouse megakaryocytes compared to mononuclear bone marrow cells |