SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm
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text
| membrane-associated colocalized with PS2 |
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shifting from nucleus to perinuclear compartment when coexpressed with M17S2 |
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localizes primarily to the sarcolemma in myocardium, where it anchors calcineurin to control its activation in coordination with the L-type Ca2+ channel |
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localizes to the plasma membrane in fibroblasts, human venous endothelial cells |
basic FUNCTION
| playing a role in kinase-phosphatase regulation of DNA and joining |
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converting the inactive conformation of integrin alpha-IIB/beta 3 to an active form through the binding to the integrin cytoplasmic domain |
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playing a dynamic role in signaling, cell death and Alzheimer's disease |
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negative regulator for PLK2 activity |
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regulates platelet aggregation in hemostasis through a specific interaction with the alphaIIb cytoplasmic domain of platelet integrin alphaIIbbeta3 |
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potential role of the CIB1/LMO3 complex is to inhibit cell proliferation |
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functions as a Ca2+-sensitive negative regulator of MAP3K5-mediated signaling events |
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binds many other proteins including presenilin 2, DNA-dependent protein kinase, the polo-like kinases PLK3 and PLK2 |
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having a function working as a Ca2+-sensitive antagonist of stress-induced signaling events |
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functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation |
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regulator of calcineurin-NFAT signaling and cardiac hypertrophy |
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necessary for pathological but not physiological hypertrophy and contributes to cardiac dysfunction during pressure overload |
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unique regulator of pathological cardiac hypertrophy and calcineurin-NFAT signaling in cardiac myocytes |
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required for permitting activation of calcineurin during maladaptive cardiac hypertrophy |
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EF-hand Ca(2+)-binding protein expressed in several cell types, including brain neurons |
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CIB1 regulates endomitosis |
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emerging roles of CIB1 in regulating cancer cell survival and angiogenesis |
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is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis |