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FLASH GENE

Symbol

CD3E

contributors: mct - updated : 01-09-2017

HGNC name	CD3E antigen, epsilon polypeptide (TiT3 complex)
HGNC id	1674

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	CD3epsilon transgenic mice, tgepsilon26, exhibits severe immunodeficiency associated with early arrest of T cell development
	mice lacking a functional Cd3e-basic-rich stretch (BRS) exhibited substantial reductions in thymic cellularity and limited CD4- CD8- double-negative (DN) 3 to DN4 thymocyte transition