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FLASH GENE
Symbol TCIRG1 contributors: mct/npt - updated : 17-09-2009
HGNC name T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3
HGNC id 11647
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cytoplasmic domain
  • seven transmembrane segments spanning domain
  • extracellular C domain
  • multiple phosphorylation sites for protein kinase C
    • HOMOLOGY
    Homologene
    FAMILY
  • V-ATPase 116 kDa subunit family
    • CATEGORY enzyme , regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • T cell membrane protein essential for T cell activation, H+, ATPase subunit
  • mediating the acidification of the bone/osteoclast interface
  • may be involved in other processes besides immune response and bone resorption
  • acting as an upstream regulatory molecule of CTLA4 expression
  • multi-subunit enzyme composed of a membrane sector and a cytosolic catalytic sector (Finbow 1991)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text vacuolar proton pomp
    PATHWAY
    metabolism
    signaling
    a component
  • component of the vacuolar proton pump
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ClCN7 that provides the chloride conductance requested for an efficient proton pump
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OPTB1
    related resource TCIRG1base: Mutation registry for autosomal recessive osteopetrosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS