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FLASH GENE

Symbol

TNFRSF18

contributors: mct - updated : 11-05-2018

HGNC name	tumor necrosis factor receptor superfamily, member 18
HGNC id	11914

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in peripherical mononuclear cells after antigen stimulation/lymphocyteactivation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	should be considered as a marker for isolating Tregs
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   TNFRSF18-TNFSF18 pathway might represent a novel target for the treatment of neuropathic pain

ANIMAL & CELL MODELS

mice lacking the glucocorticoid-induced tumor necrosis factor receptor related protein (Gitr) exhibit defective CD8 T cell accumulation, increased T cell exhaustion and impaired viral control