Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TANK contributors: mct/npt/pgu - updated : 02-11-2015
HGNC name TRAF family member-associated NFKB activator
HGNC id 11562
Location 2q24.2      Physical location : 161.993.465 - 162.092.682
Synonym name
  • tumor necrosis receptor-associated factor,TRAF-interacting protein,mediator of NFKB activation
  • TRAF interacting protein TANK
    • Synonym symbol(s) I-TRAF, TRAF2, ITRAF
    DNA
    TYPE functioning gene
    STRUCTURE 99.25 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D2S156 - TANK - D2S376 - qter
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 2089 47.6 425 - 2007 17568778
    4 splicing 698 13 119 - 2007 17568778
    different C terminus
    8 - 2060 - 425 - 2007 17568778
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousgangliasensory gangliadorsal root   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a negatively acting C terminus
    • HOMOLOGY
    interspecies homolog to murine Tank
    Homologene
    FAMILY
  • TRAF family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • mediator of NFKB activation after induction by TRAF2
  • essential for the efficient induction of IRF-dependent transcription, as are two further TBK1 adaptors, AZI2 and TBKBP1
  • TANK with AZI2 or TBKBP1 assemble TBK1 and IKKE complexes
  • required for the TBK1- and IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex
  • dispensable role for the early phase of double-stranded RNA-mediated IRF3 phosphorylation
  • may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in multiple antiviral pathways
  • negative feedback regulator of osteoclastogenesis and osteoblastogenesis
  • TANK is critical for osteoclastogenesis by regulating NFKB1, and is also important for proper bone remodeling
  • inhibits the bone resorption activity of bone marrow-derived osteoclasts
  • negatively regulate the ubiquitination of TRAF proteins, and TANK serves as an important negative regulator of NFKB1 signaling cascades induced by genotoxic stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • TANK formed a complex with ZC3H12A and a deubiquitinase, USP10, which was essential for the USP10-dependent deubiquitination of TRAF6 and the resolution of genotoxic NFKB1 activation upon DNA damage
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding and sequestering to the TRAF C domain of TRAF1, TRAF2, TRAF3 thereby inhibiting TRAF signaling pathway
  • associating with IKBG, with subsequent connection of IKK complexes with IKBE and IKB1 resulting
  • MARCH5 catalyzes the K63-linked poly-ubiquitination of TANK, thus impairing the ability of TANK to inhibit TRAF6
  • negatively regulates TRAF6 ubiquitination and RELA activation, and its overexpression attenuates osteoclast differentiation
  • TANK, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NFKB1 activity and CFLAR expression
  • negatively regulates NFKB1 activation by DNA damage via inhibiting ubiquitination of TRAF6
    • cell & other
    REGULATION
    Other regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor SOX11
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in response to peripheral nerve injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    methods for the inhibition and stimulation of TANK in osteoblasts and osteoclasts, respectively, may be a reasonable strategy to manipulate bone-destructive diseases
    ANIMAL & CELL MODELS
  • osteoblastogenesis was also increased in Tank-deficient mice
  • Tank-/- mice spontaneously develop autoimmune glomerular nephritis in an IL6-dependent manner