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FLASH GENE
Symbol SIGLEC6 contributors: npt/ - updated : 23-01-2007
HGNC name sialic acid binding Ig-like lectin 6
HGNC id 10875
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinesmall intestine   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three Ig-like domains
  • a cytoplasmic tail
  • two immunoreceptor tyrosine based inhibitory motifs (ITIM) the second of these motifs matching a sequence found in (signaling lymphocyte activating molecule) SLAM and SLAM-like protein
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
    • CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediating cell-cell recognition
  • also binding leptin and potentially modulator of leptin levels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of transmembrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • leptin binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS