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FLASH GENE

Symbol

SIGLEC6

contributors: npt/ - updated : 23-01-2007

HGNC name	sialic acid binding Ig-like lectin 6
HGNC id	10875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2076 - 453 - - variant 2 - - 2028 - 437 - - variant 3 - - 1900 - 353 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive intestine small intestine

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three Ig-like domains
	a cytoplasmic tail
	two immunoreceptor tyrosine based inhibitory motifs (ITIM) the second of these motifs matching a sequence found in (signaling lymphocyte activating molecule) SLAM and SLAM-like protein

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	SIGLEC (sialic acid binding Ig-like lectin) family

CATEGORY

antigen , receptor

SUBCELLULAR LOCALIZATION

basic FUNCTION	mediating cell-cell recognition
	also binding leptin and potentially modulator of leptin levels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

protein constituent of transmembrane

INTERACTION

DNA

RNA

small molecule

protein

leptin binding

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS