Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SIGLEC6

contributors: npt/ - updated : 23-01-2007

HGNC name	sialic acid binding Ig-like lectin 6
HGNC id	10875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.3      Physical location : 52.022.783 - 52.035.110
Synonym name	cell differentiation antigen CD33-like 1
	CD33 antigen-like 1
	CD327 antigen
	obesity-binding protein 1
Synonym symbol(s)	OB-BP1, CD33L1, CD33L, SIGLEC-6, CD327, CDw327

DNA

TYPE	functioning gene
STRUCTURE	12.08 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2076 - 453 - - variant 2 - - 2028 - 437 - - variant 3 - - 1900 - 353 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive intestine small intestine

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three Ig-like domains
	a cytoplasmic tail
	two immunoreceptor tyrosine based inhibitory motifs (ITIM) the second of these motifs matching a sequence found in (signaling lymphocyte activating molecule) SLAM and SLAM-like protein

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	SIGLEC (sialic acid binding Ig-like lectin) family

CATEGORY

antigen , receptor

SUBCELLULAR LOCALIZATION

basic FUNCTION	mediating cell-cell recognition
	also binding leptin and potentially modulator of leptin levels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

protein constituent of transmembrane

INTERACTION

DNA

RNA

small molecule

protein

leptin binding

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS