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FLASH GENE
Symbol ANGPT4 contributors: - updated : 07-04-2006
HGNC name angiopoietin 4
HGNC id 487
Location 20p13      Physical location : 853.298 - 896.960
Synonym name angiopoietin 3
Synonym symbol(s) ANG4, ANG-3, AGP4
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text a major 5- and a minor 4-kb transcript (Valenzuela, 1999)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an N terminal region lacking homology to any known structure
  • a fibrinogen-like domain at the C terminus
    • secondary structure
  • an alpha-helical rich coiled-coil segment
    • isoforms Precursor a 479 aa mature peptide
    HOMOLOGY
    interspecies homolog to murine Angpt4
    homolog to rattus Agpt4
    intraspecies homolog to ANGTP1
    homolog to ANGPT2
    Homologene
    FAMILY
  • vascular endothelial growth factor family
  • angiopoietin family
    • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK, including phosphorylation of TEK
  • promoting angiogenic remodeling as well as vessel maturation and stabilization
  • activating tyrosine-protein kinase receptor tie 2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component Binds to tyrosine-protein kinase receptor TIE2 and activates it
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • tyrosine-protein kinase receptor tie 2
    • cell & other
    REGULATION
    repressed by vascular endothelial cell growth factor
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS