Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

NTN1

contributors: mct - updated : 28-04-2017

HGNC name	netrin 1
HGNC id	8029

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in brain tumor and neuroblastama constitutional     --over   in epithelial cells of ulcerative colitis, and Crohn disease, and required for colorectal cancer progression (Paradisi 2009) tumoral     --over   strongly upregulated in ovarian malignant tumors but not in benign tumors tumoral     --over   in inflammatory bowel diseases is required for colorectal cancer progression (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may represent a novel candidate biomarker for ovarian cancer
Therapy target
	System Type Disorder Pubmed cancer digestive colon inhibition of NTN1 could be an innovative target for drug therapy in inflammation-driven colorectal cancers

ANIMAL & CELL MODELS