Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NCR2 contributors: mct - updated : 09-03-2012
HGNC name natural cytotoxicity triggering receptor 2
HGNC id 6732
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single extracellular V-type domain
  • a single transmembrane segment
  • potential N and O linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila Cg7564
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • natural cytotoxicity receptor (NCR) family
    • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • major activating receptor involved in the recognition and lysis of tumor cells
  • IL3-mediated induction of NCR2 on IPCs (interferon-producing cells) may be an important component of the ongoing crosstalk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus
  • playing a role in natural killer cell activation
  • NCR1, NCR2, NCR3 are thought to be NK lineage restricted
  • mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells
  • with NCR1 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TYROBP
  • LAIR1, highly expressed by plasmacytoid dendritic cells, acts complementary with NCR2 to control IFNA production
  • interaction with PCNA inhibits NK cell function through NCR2/ITIM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS