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FLASH GENE

Symbol

NCR2

contributors: mct - updated : 09-03-2012

HGNC name	natural cytotoxicity triggering receptor 2
HGNC id	6732

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	15.10 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004828 5 - 941 isoform1 30.7 276 - 1999 10049942 IL2 activated NK cells variant 2 - - 3700 isoform 2 - - - 1999 10049942 IL2 activated NK cells NM_001199509 6 - 1084 - 270 - 1999 10049942 NM_001199510 6 - 1048 NP_001186439 - 258 - 1999 10049942

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Homo sapiens   tonsils         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune activated B lymphocyte Lymphoid/Immune dendritic cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single extracellular V-type domain
	a single transmembrane segment
	potential N and O linked glycosylation sites

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to Drosophila Cg7564

Homologene

FAMILY	immunoglobulin superfamily
	natural cytotoxicity receptor (NCR) family

CATEGORY

antigen , receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	major activating receptor involved in the recognition and lysis of tumor cells
	IL3-mediated induction of NCR2 on IPCs (interferon-producing cells) may be an important component of the ongoing crosstalk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus
	playing a role in natural killer cell activation
	NCR1, NCR2, NCR3 are thought to be NK lineage restricted
	mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells
	with NCR1 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to TYROBP
	LAIR1, highly expressed by plasmacytoid dendritic cells, acts complementary with NCR2 to control IFNA production
	interaction with PCNA inhibits NK cell function through NCR2/ITIM

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS