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FLASH GENE
Symbol UBD contributors: mct/pgu - updated : 09-07-2016
HGNC name ubiquitin D
HGNC id 18795
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in hepatocellular carcinoma and in several gastrointestinal and gynecological cancers
constitutional     --over  
in cells lead to increased mitotic nondisjunction and chromosome instability, and this effect is mediated by an abbreviated mitotic phase and the reduction in the kinetochore localization during the prometaphase stage of the cell cycle
constitutional     --over  
led to chromosomal instability that is mediated by an abbreviated mitotic phase
constitutional     --over  
in the heart at the border zone of myocardial infarction
tumoral     --over  
significantly correlated with poor survival in pancreatic ductal adenocarcinoma (PDAC) patients
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may be involved in gastric carcinogenesis, and is a potential marker for the prognosis of gastric cancer patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    interaction of FAT10 with MAD2L1 is a key mechanism underlying the promalignant property of UBD and offer prospects for the development of anticancer strategies
    ANIMAL & CELL MODELS