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FLASH GENE

Symbol

HCN2

contributors: mct/npt/pgu - updated : 18-03-2019

HGNC name	hyperpolarization activated cyclic nucleotide-gated potassium channel 2
HGNC id	4846

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     gain of function in Genetic generalized epilepsy (GGE) constitutional     --over   in chronic inflammation resulting in an increased expression of HCN2 and causing sensitization in peripheral and spinal terminals of the pain transduction pathway constitutional germinal mutation       contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   HCN2-selective blockers may have value as analgesics to combat both inflammatory and neuropathic pain neurology neurodegenerative alzheimer silencing or inhibition of HCN2 affects APP processing and thereby could serve as a potential treatment strategy

ANIMAL & CELL MODELS

mutation in HCN2 likely leads to impaired gastrointestinal motility, causing the severe growth restriction seen in mice with mutations that eliminate HCN2 expression