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FLASH GENE
Symbol PTPRB contributors: - updated : 22-07-2006
HGNC name protein tyrosine phosphatase, receptor type, B
HGNC id 9665
Location 12q15      Physical location : 70.910.633 - 71.031.219
Synonym name protein tyrosine phosphatase, receptor type, beta polypeptide
Synonym symbol(s) FLJ44133, HPTP-BETA, HPTPB, MGC142023, PTPB, R-PTP-BETA
EC.number 3.1.3.48
DNA
TYPE functioning gene
STRUCTURE 88.00 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   highly
Urinarybladder   highly
 kidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 17 fibronectin type-III domains
  • a tyrosine-protein phosphatase domain
  • HOMOLOGY
    Homologene
    FAMILY protein-tyrosine phosphatase family, receptor class 3 subfamily
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may regulate sodium channels by altering tyrosine phosphorylation status
  • play a role in cell adhesion, neurite growth, and neuronal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with sodium channels
  • interaction with tenascin C, through the FNIII domain to mediate cell adhesion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS