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FLASH GENE

Symbol

CLK1

contributors: mct/npt - updated : 07/11/2008

HGNC name	CDC-like kinase 1
HGNC id	2068

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CLK1 (long) 13 - 1887 57 484 - Johnson, Olsen (2006) active (short) - - - - 136 prostate, testis, muscle, leukocytes Hanes, Olsen (2006) lacking the kinase domain

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear       highly Lymphoid/Immune spleen       highly   thymus       predominantly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	LAMMER family
	carboxylate-bridged diiron family of proteins

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may play an indirect role in governing splice site selection
	phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS