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FLASH GENE
Symbol CLK1 contributors: mct/npt - updated : 07/11/2008
HGNC name CDC-like kinase 1
HGNC id 2068
Location 2q33      Physical location : 201.717.731 - 201.729.467
Synonym name
  • CDC28/CDC2-like kinase
  • dual specificity protein kinase CLK1
  • protein tyrosine kinase STY
    • Synonym symbol(s) CAT5, CLK, CLK/STY
    EC.number 2.7.12.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.69 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1887 57 484 - Johnson, Olsen (2006)
  • active
    • - - - - 136 prostate, testis, muscle, leukocytes Hanes, Olsen (2006)
  • lacking the kinase domain
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
     thymus   predominantly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • LAMMER family
  • carboxylate-bridged diiron family of proteins
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play an indirect role in governing splice site selection
  • phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS