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FLASH GENE
Symbol CLK1 contributors: mct/npt - updated : 07/11/2008
HGNC name CDC-like kinase 1
HGNC id 2068
Location 2q33      Physical location : 201.717.731 - 201.729.467
Synonym name
  • CDC28/CDC2-like kinase
  • dual specificity protein kinase CLK1
  • protein tyrosine kinase STY
  • Synonym symbol(s) CAT5, CLK, CLK/STY
    EC.number 2.7.12.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 11.69 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SATB2 2q32-q33 SATB family member 2 FLJ32063 2q33.1 hypothetical protein FLJ32063 LOC389069 2 similar to selenophosphate synthetase 1 LOC389070 2 LOC389070 FLJ38973 2q33.1 hypothetical protein FLJ38973 FLJ37953 2q33.1 hypothetical protein FLJ37953 FLJ22555 2q33.1 hypothetical protein FLJ22555 DNAPTP6 2q33.2 DNA polymerase-transactivated protein 6 FLJ37818 2q33.2 hypothetical protein FLJ37818 FLJ31322 2q33.2 hypothetical protein FLJ31322 TRIPIN 2q33.2 tripin AOX1 2q33 aldehyde oxidase 1 AOX2 2q33.2 aldehyde oxidase 2 BZW1 2q33 basic leucine zipper and W2 domains 1 LOC391472 2 similar to bA476B13.3 (KIAA0699 protein) CLK1 2q33 CDC-like kinase 1 PPIL3 2q33 peptidylprolyl isomerase (cyclophilin)-like 3 NIF3L1 2q33-q34 NIF3 NGG1 interacting factor 3-like 1 (S. pombe) ORC2L 2q33 origin recognition complex, subunit 2-like (yeast) MGC39518 2q33.2 hypothetical protein MGC39518 NDUFB3 2q31.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa CFLAR 2q33 CASP8 and FADD-like apoptosis regulator CASP10 2q33-q34 caspase 10, apoptosis-related cysteine protease CASP8 2q33-q34 caspase 8, apoptosis-related cysteine protease ALS2CR12 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 ALS2CR3 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 ALS2CR2 2q33-q34 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 FLJ25351 2q33.2 hypothetical protein FLJ25351 ALS2CR4 2q33 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4 MPP4 2q33.2 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) ALS2 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) LOC151256 2q33.2 hypothetical LOC151256 ALS2CR7 2q33.2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7 FZD7 2q33 frizzled homolog 7 (Drosophila) FLJ39061 2q33.2 hypothetical protein FLJ39061 LOC339809 2q33.2 KIAA2012 protein UBL1 2q32.3-q33 ubiquitin-like 1 (sentrin) NOP5/NOP58 2q33.2 ubiquitin-like 1 (sentrin) BMPR2 2q33-q34 bone morphogenetic protein receptor, type II (serine/threonine kinase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1887 57 484 - Johnson, Olsen (2006)
  • active
  • - - - - 136 prostate, testis, muscle, leukocytes Hanes, Olsen (2006)
  • lacking the kinase domain
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunespleen   highly
     thymus   predominantly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • LAMMER family
  • carboxylate-bridged diiron family of proteins
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play an indirect role in governing splice site selection
  • phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS