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FLASH GENE
Symbol MSC contributors: mct - updated : 07-03-2007
HGNC name musculin (activated B-cell factor-1)
HGNC id 7321
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) with transcription inhibition domain,
  • putative nuclear localization signal (NLS),
  • a glycine rich region
  • a stretch of acidic residues
    • HOMOLOGY
    interspecies homolog to murine Musculin
    Homologene
    FAMILY basic helix-loop-helix family of transcription factor
    CATEGORY immunity/defense , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • maybe involved in regulating antigen-dependent B cell differentiation
  • nuclear transcriptional repressor
  • may play important roles not only in developmental processes but also in regenerative processes in adult tissue
  • may be involved in rapid down-regulation of MYOD1 in muscle regeneration
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    downstream target of the B cell receptor/signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein ID2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in acute renal failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS