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FLASH GENE
Symbol MSC contributors: mct - updated : 07-03-2007
HGNC name musculin (activated B-cell factor-1)
HGNC id 7321
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Reproductivefemale systemplacenta  highly
Respiratorylung    
Skin/Tegumentskin   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines EBV immortalized lymphoblastoid cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) with transcription inhibition domain,
  • putative nuclear localization signal (NLS),
  • a glycine rich region
  • a stretch of acidic residues
  • HOMOLOGY
    interspecies homolog to murine Musculin
    Homologene
    FAMILY basic helix-loop-helix family of transcription factor
    CATEGORY immunity/defense , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • maybe involved in regulating antigen-dependent B cell differentiation
  • nuclear transcriptional repressor
  • may play important roles not only in developmental processes but also in regenerative processes in adult tissue
  • may be involved in rapid down-regulation of MYOD1 in muscle regeneration
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    downstream target of the B cell receptor/signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein ID2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in acute renal failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS