Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GFPT2 contributors: mct - updated : 24-08-2010
HGNC name glutamine-fructose-6-phosphate transaminase 2
HGNC id 4242
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a type-2 glutamine amidotransferase domain
    • HOMOLOGY
    interspecies homolog to murine Gfpt2
    homolog to C.elegans f22b3.4
    intraspecies homolog to GFPT1
    Homologene
    FAMILY
  • SIS family
  • GFAT subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in regulating the availability of
    • precursors for N- and O-linked glycosylation of proteins
  • rate-limiting enzyme in hexosamine biosynthesis (Zitzler 2004)
  • critical target of methylmercury and ROS-induced cytotoxicity (Zitzler 2004)
  • involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor (Tondreau 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between GFPT2 with TGF-beta1 genes (Prasad 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP I471V associated with type 2 diabetes
    Candidate gene
    Marker
    Therapy target
  • relevant target for pharmacological intervention in chronic renal insufficiency of type-2 diabetes (Prasad 2010)
    • ANIMAL & CELL MODELS