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FLASH GENE

Symbol

APEX1

contributors: mct/pgu - updated : 06-04-2013

HGNC name	APEX nuclease (multifunctional DNA repair enzyme) 1
HGNC id	587

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Ref1 -/- mice died during embryonic development following blastocyst formation after implantation
	APE1+/- mice are Ape haploinsufficient with a 40 to 50% reduction in Ape mRNA, protein, and 5-prime endonuclease activity in liver, brain and testis