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FLASH GENE

Symbol

NUP155

contributors: mct/npt/pgu - updated : 29-05- 201

HGNC name	nucleoporin 155kDa
HGNC id	8063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a leucine zipper in the N terminal region and 46 consensus sites for various kinases and
	the GVRLFF motif common of the nucleoporins of the same class
	a 177 C-terminal amino acid span that binds to GLE1

HOMOLOGY

Homologene

FAMILY

non repetitive/WGA-negative class

CATEGORY

structural protein , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
	intracellular,nuclear envelope,pore
text	direct pore membrane binding of NUP155 is critical for Nuclear pore complexes (NPCs) formation

basic FUNCTION	involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm
	may act as a key upstream gene that causes atrial fibrillation by regulating the expression of downstream genes by controlling mRNA nucleocytoplasmic export

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	nucleocytoplasmic bilateral transport of macromolecule

PATHWAY

metabolism

signaling

constituent of the nuclear pore complex involved in cellular nucleo-cytoplasmic transport

a component	NPC subcomplex containing NUP93, NUP155, and NUP205
	NUP155, GLE1, and nucleoporin NUPL2 form a heterotrimeric complex
	formation of a NUP35-NUP155 complex plays a critical role in the processes of nuclear envelope (NE) and nuclear pore complexes assembly

INTERACTION

DNA

RNA

small molecule

protein	interaction with GLE1 (GLE1 association may represent a step in the GLE1-mediated mRNA export pathway)
	interact with NUP93, NUP35 and NUP205
	N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
	NUP155 is an HDAC4-interacting protein (NUP155-mediated localization was required for HDAC4 effect on gene expression)
	interaction of NUP35 and NUP155 has a crucial role in NPC formation as the main determinant of recruitment of NUP155 to the assembling pore
	negative regulatory loop within the nuclear pore complex (NPC) controlling the chromatin attachment state, in which NUP155 and NUP93 recruit NUP62 to suppress chromatin tethering by NUP155
	self-interaction between the N- and C-terminal domains of NUP155 has an auto-inhibitory function that prevents interaction between the N terminus of NUP155 with the C-terminal region of NUP35

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ATFB10

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation     loss of function causes atrial fibrillation by altering mRNA and protein transport and link the nuclear pore complex to cardiovascular disease constitutional   deletion     in mental and developmental retardation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular rythm   may facilitate the development of new diagnostic and therapeutic tools for prevention and treatment of atrial fibrillation

ANIMAL & CELL MODELS