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FLASH GENE
Symbol NUP155 contributors: mct/npt/pgu - updated : 29-05- 201
HGNC name nucleoporin 155kDa
HGNC id 8063
Corresponding disease
ATFB10 atrial fibrillation, familial, 10
Location 5p13.2      Physical location : 37.291.940 - 37.371.197
Synonym name nuclear pore complex protein Nup155
Synonym symbol(s) KIAA0791, N155
DNA
TYPE functioning gene
STRUCTURE 79.00 kb     35 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3 LOC345513 5p13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) IDN3 5p13.2 IDN3 protein LOC391777 5 similar to ribosomal protein S4, X-linked FLJ13231 5p13.2 hypothetical protein FLJ13231 LOC389283 5 LOC389283 OFD1P1 5p13 oral-facial-digital syndrome 1, pseudogene 1 NUP155 5p13 nucleoporin 155kDa FLJ10233 5p13.2 hypothetical protein FLJ10233 GDNF 5p13-p12 glial cell derived neurotrophic factor FLJ39155 5p13.2 hypothetical protein FLJ39155 LIFR 5p13-p12 leukemia inhibitory factor receptor LOC253254 5p13.2 hypothetical LOC253254 OSMR 5p13.2 oncostatin M receptor KIAA1999 MGC39830 5p13.2 hypothetical protein MGC39830 FYB 5p13.1 FYN binding protein (FYB-120/130) C9 5p13 complement component 9 DAB2 5p13-p12.1 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
35 polyA site 4355 155 1391 - 2005 15703211
35 polyA site 4200 - 1332 - 2005 15703211
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine zipper in the N terminal region and 46 consensus sites for various kinases and
  • the GVRLFF motif common of the nucleoporins of the same class
  • a 177 C-terminal amino acid span that binds to GLE1
  • HOMOLOGY
    Homologene
    FAMILY non repetitive/WGA-negative class
    CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm
  • may act as a key upstream gene that causes atrial fibrillation by regulating the expression of downstream genes by controlling mRNA nucleocytoplasmic export
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nucleocytoplasmic bilateral transport of macromolecule
    PATHWAY
    metabolism
    signaling
    constituent of the nuclear pore complex involved in cellular nucleo-cytoplasmic transport
    a component
  • NPC subcomplex containing NUP93, NUP155, and NUP205
  • NUP155, GLE1, and nucleoporin NUPL2 form a heterotrimeric complex
  • formation of a NUP35-NUP155 complex plays a critical role in the processes of nuclear envelope (NE) and nuclear pore complexes assembly
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with GLE1 (GLE1 association may represent a step in the GLE1-mediated mRNA export pathway)
  • interact with NUP93, NUP35 and NUP205
  • N terminus of POM121 directly binds the beta-propeller regions of NUP155 and NUP160
  • NUP155 is an HDAC4-interacting protein (NUP155-mediated localization was required for HDAC4 effect on gene expression)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATFB10
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    causes atrial fibrillation by altering mRNA and protein transport and link the nuclear pore complex to cardiovascular disease
    constitutional   deletion    
    in mental and developmental retardation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularrythm 
    may facilitate the development of new diagnostic and therapeutic tools for prevention and treatment of atrial fibrillation
    ANIMAL & CELL MODELS