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FLASH GENE
Symbol CDH18 contributors: - updated : 26-07-2005
HGNC name cadherin 18, type 2
HGNC id 1757
Location 5p15.2-p15.1      Physical location : 19.473.156 - 19.988.353
Synonym name cadherin-like 24, EY-cadherin
Synonym symbol(s) CDH14, CDH24, CDH14L, EY-CADHERIN
DNA
TYPE functioning gene
STRUCTURE 515.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D5S478 - D5S1954 - CDH18 - CDH12 - CDH6 - cen
Authors Chalmers (99)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systemovary  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal hydrophobic domain
  • five extracellular cadherin repeats with four cysteines in the most proximal
  • a transmembrane segment
  • a highly conserved cytoplasmic tail required for interactions
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell adhesion molecule, putatively involved in synaptic adhesion
  • involved in axon outgrowth and guidance
  • playing a role in cell-cell or cell-ECM interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • hemophilic,calcium dependent interactions
  • interacting by its C terminus with the cytoskeleton via beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS