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FLASH GENE
Symbol GNA14 contributors: mct - updated : 19-09-2016
HGNC name guanine nucleotide binding protein (G protein), alpha 14
HGNC id 4382
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GTPase domain made of three regions named switches 1,2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Gna14
    homolog to C.elegans mo1d7.7
    Homologene
    FAMILY
  • G-alpha family
  • G(q) subfamily
    • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • mediating pertussis toxin-resistant stimulation of phospholipase C beta
  • cell fate specification
  • palmitoylated at distinct polycysteine sequences, and the adjacent polybasic domain is not required for Galpha palmitoylation but is important for localization and functional activity of heterotrimeric G proteins
  • GNA12 and GNA14 play a key role in the genetic architecture underlying normal gray matter density (GMD) variation in frontal and parietal regions
  • GNA11 and GNA14 induce changes in cellular morphology and growth-factor independence via MAPK activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterotrimeric G protein GTPase, alpha subunit
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • beta and gamma subunits of the trimeric G protein
  • TTC1 is required for GNA14 to stimulate RAS-dependent signaling pathways, but not for the propagation of signals along RAS-independent pathways
  • previously identified PLCB1-interacting AAs are insufficient to ensure productive interaction of GNA14 with PLCB1, while an intact N-terminal half of GNA14 is apparently required for PLCB1 interaction
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    tumoral somatic mutation      
    in congenital tufted angiomas (TAs), kaposiform hemangioendotheliomas (KHEs), and childhood lobular capillary hemangiomas (LCHs)
    constitutional     --over  
    severe preeclamptic (sPE) human placentas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS