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FLASH GENE
Symbol EIF4EBP3 contributors: - updated : 12-10-2007
HGNC name eukaryotic translation initiation factor 4E binding protein 3
HGNC id 3290
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
Respiratoryrespiratory tractlarynx  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • middle region containing the EIF4E binding motif
  • phosphorylation sites
    • secondary structure an alpha helical structure involved in the control translation initiation
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Eif4ebp3
    intraspecies paralog to EIF4EBP1
    paralog to EIF4EBP2
    Homologene
    FAMILY EIF4EBP family
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • translational repressor,negatively regulating translation by eIF4E (overexpression specifically reduces EIF4E-dependent translation)
  • acting as a tumor suppressor
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembling with eIF4A, eIF4B, eIF4E, eIF4EBP1, eIF4EBP2, MNK1, eIF4G and PABPC1 to form the eukaryotic translation initiation complex eIF4F
    • INTERACTION
    DNA
    RNA
    small molecule
    protein binding to EIF4E into the nucleus
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ANKHD1 in leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for cancer therapy, potentially (small-molecule inhibitors that pharmacologically mimic function)
    ANIMAL & CELL MODELS