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FLASH GENE

Symbol

EIF4EBP3

contributors: - updated : 12-10-2007

HGNC name	eukaryotic translation initiation factor 4E binding protein 3
HGNC id	3290

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 698 variant 1 10 100 - Poulin variant 2 / fusion protein - - 8319 variant 2 / fusion protein 277 2617 - Poulin Co-transcription with ANKHD1 (the neighboring upstream gene) generates a transcript (MASK-BP3) encoding a fusion protein comprised of the majority of the MASK protein sequence and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments infrequent but naturally occurring co-transcript product unknown function

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly Respiratory respiratory tract larynx     highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	middle region containing the EIF4E binding motif
	phosphorylation sites

secondary structure

an alpha helical structure involved in the control translation initiation

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to murine Eif4ebp3

intraspecies	paralog to EIF4EBP1
	paralog to EIF4EBP2

Homologene

FAMILY

EIF4EBP family

CATEGORY

regulatory , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus

basic FUNCTION	translational repressor,negatively regulating translation by eIF4E (overexpression specifically reduces EIF4E-dependent translation)
	acting as a tumor suppressor

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

assembling with eIF4A, eIF4B, eIF4E, eIF4EBP1, eIF4EBP2, MNK1, eIF4G and PABPC1 to form the eukaryotic translation initiation complex eIF4F

INTERACTION

DNA

RNA

small molecule

protein

binding to EIF4E into the nucleus

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with ANKHD1 in leukemia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	for cancer therapy, potentially (small-molecule inhibitors that pharmacologically mimic function)

ANIMAL & CELL MODELS