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FLASH GENE
Symbol CD3D contributors: mct - updated : 01-09-2017
HGNC name CD3d molecule, delta (CD3-TCR complex)
HGNC id 1673
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig extracellular domain
  • a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM)
  • highly evolutionarily conserved CXXC motif
  • a short extracellular stalk connecting its Ig-like domains to its transmembrane regions
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Cd3d
    homolog to rattus Cd3d
    homolog to C.elegans K01A2.2
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text type I membrane protein
    basic FUNCTION
  • playing an essential role in promoting progression of early thymocytes toward double-positive stage
  • acting as a T-cell receptor
  • the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane
  • CD3G and CD3D evolved from a common precursor gene to optimize peptide/MHC-triggered alphabeta TCR activation
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text
  • thymocyte development
    • PATHWAY
    metabolism hormone
    signaling signal transduction
    a component
  • constituent after pre T cell antigen reception complex
  • CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD19
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in patients with aplastic anemia (AA)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS