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FLASH GENE

Symbol

CD3D

contributors: mct - updated : 01-09-2017

HGNC name	CD3d molecule, delta (CD3-TCR complex)
HGNC id	1673

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, head to head
text	see CD3@
	head to head with CD3G
	clustered with CD3epsilon, CD3gamma
STRUCTURE	5.16 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000732 5 - 771 NP_000723 18 171 - 1991 1831653 NM_001040651 4 - 639 NP_001035741 - 127 - 1991 1831653 lacking an exon in the coding region and the transmembrane domain

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly   thymus       highly Reproductive male system prostate     moderately

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Ig extracellular domain
	a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM)
	highly evolutionarily conserved CXXC motif
	a short extracellular stalk connecting its Ig-like domains to its transmembrane regions

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Cd3d
	homolog to rattus Cd3d
	homolog to C.elegans K01A2.2

Homologene

FAMILY

immunoglobulin superfamily

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	type I membrane protein

basic FUNCTION	playing an essential role in promoting progression of early thymocytes toward double-positive stage
	acting as a T-cell receptor
	the stalks of the CD3G, CD3E, CD3D, CD247 may be critical in transmitting part of the activation signal directly through the membrane
	CD3G and CD3D evolved from a common precursor gene to optimize peptide/MHC-triggered alphabeta TCR activation

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development , immunity/defense

text	thymocyte development

PATHWAY

metabolism

hormone

signaling

signal transduction

a component	constituent after pre T cell antigen reception complex
	CD3D/CD28-inducible FAU/BCL2L14 complex may be involved in the regulation of T cell function and survival

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IMD19

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients with aplastic anemia (AA)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS