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FLASH GENE
Symbol PFDN1 contributors: npt/ - updated : 08-03-2008
HGNC name prefoldin subunit 1
HGNC id 8866
DNA
TYPE functioning gene
STRUCTURE 58.05 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1324 14.08 122 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , hexamer
HOMOLOGY
interspecies homolog to C.elegans C08F8.1
intraspecies homolog to keratin
Homologene
FAMILY
  • prefolding beta subunit family
    • CATEGORY chaperone/stress , structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin (C-CPN)(Vainberg 1998)
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathway for nonnative proteins
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN)
  • binding to nascent polypeptide chain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS