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FLASH GENE
Symbol LEFTY1 contributors: mct/npt - updated : 25-05-2010
HGNC name left-right determination factor 1
HGNC id 6552
Location 1q42.12      Physical location : 226.073.982 - 226.076.836
Synonym name
  • left-right determination, factor B
  • lefty-B protein
  • protein lefty-1
  • Synonym symbol(s) LEFTY2, LEFTB, LEFTYB
    DNA
    TYPE functioning gene
    STRUCTURE 2.86 kb     4 Exon(s)
    regulatory sequence Binding site   enhancer
    text structure an asymetric enhancer (ASE) for left expression
    MAPPING cloned Y linked N status provisional
    regionally located separated to LEFTA by approximately 50kb on 1q42
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1647 - 366 - Kosaki (1999)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningendometrium highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text left side of the embryo, more strongly in the lateral plate than in the floor plate mesoderm
  • seemed to be exclusively expressed by a certain population of cells in the early human embryoid bodies that does not overlap with the population expressing the ESC marker OCT4 (Dvash 2007)
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • precursor protein containing a N terminal TGFB1 sequence
  • two cleavage sites
  • six cysteine residues asymetry
  • HOMOLOGY
    interspecies homolog to murine Leftb
    intraspecies homolog to LEFTA/EBAF
    Homologene
    FAMILY
  • TGF-beta family of growth factors
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • play a role in left-right determination
  • its expression controlled by NODAL appears to have a substantial role in mesodermal origin cell population establishment, since inhibition of NODAL activity downregulated expression not only of LEFTY1 and LEFTY2 but also of BRACHYURY, an early mesodermal marker (Dvash 2007)
  • acts as a molecular switch that modulates both the induction of decidual differentiation and the maintenance of a decidualized state (Tang 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text embryogenesis and morphogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    TGF -beta receptor signaling pathway
    a component
  • central component with EBAF, NODAL, PITX2, of the left-right asymetry determination
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • antagonizing NODAL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Lefty2-/- mice