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FLASH GENE
Symbol LRP12 contributors: - updated : 08-11-2005
HGNC name low density lipoprotein-related protein 12
HGNC id 31708
Location 8q22.2-q23.1      Physical location : 105.501.458 - 105.601.252
Synonym name suppression of tumorigenicity 7
Synonym symbol(s) FLJ12929, ST7
DNA
TYPE functioning gene
STRUCTURE 100.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a five fold cysteine-rich repeat homolog to the ligand binding repeat of LDLR
  • an hydrophobic stretch
  • a C terminal domain of 343 residues
  • two CUB domains
  • five LDL-receptor class A domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 2
    basic FUNCTION
  • putative ST7 receptor protein, with potential role in the transformation process of cells
  • may function as an oncogene in oral tumors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component protein constituent of transmembrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS