motifs/domains
| BTB/POZ-domain at its N terminus, |
|
four C2H2-type zinc fingers |
|
ten potential sumoylation sites located at lysines 61, 354, 371, 379, 383, 396, 486, 487, 536 and 539 (Roh 2007) |
|
a POZ (poxvirus zinc finger) domain, as an NRE-binding protein |
|
a Krüppel-like zinc finger at its C terminus (Jeon 2008) |
basic FUNCTION
| may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation |
|
BTB/POZ-domain Krüppel-like zinc-finger transcription factor acting as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription (Jeon 2008) |
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represses transcription of ADH5 and CDKN2A |
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can specifically stimulate Tat-activated HIV-1 transcription |
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represses the production of the tumor suppressor CDKN2A |
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may be an active participant in the differentiation process |
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plays an important role in adipogenesis, osteogenesis, oncogenesis, and transcription of NF-kB responsive genes (Roh 2007) |
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activity as a transcription factor may involve sumoylation, and sumoylation might be important in the regulation of transcription by ZBTB7A (Roh 2007) |
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may be involved in the transcriptional regulation of the genes involved in differentiation, cell cycle control, and tumor suppression, such as RB1 (Jeon 2008) |
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key transcriptional cascade for effective erythropoiesis, whereby GATA1 suppresses BCL2L11-mediated apoptosis via ZBTB7A |
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plays stage-specific distinct roles in osteoclast differentiation, exemplifying the delicate transcriptional regulation at work in lineage commitment |
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plays critical roles in regulating lymphoid lineage commitment, mature B-cell development, and the germinal center (GC) response via distinct mechanisms |
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ZBTB7A, ZBTB7B pair are a core node of Th cell differentiation and function |
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is necessary for Hematopoietic stem cells (HSCs) maintenance by functioning as an erythroid-specific repressor of Delta-like 4 (DLL4) expression |
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has a critical oncosuppressive role in the prostate |
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is a context-dependent cancer gene that can act as an oncogene in some contexts but also has oncosuppressive-like activity in PTEN-null tumors |
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novel tumor suppressor role of ZBTB7A in directly suppressing glycolysis. |
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plays an important role in oncogenic transformation and tumorigenesis |
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previously unrecognized role of ZBTB7A in negative regulation of melanoma metastasis, having important clinical implications |
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master oncogene crucial for the tumorigenicity and progression of a variety of cancers, demonstrated to enhance the proliferation and survival of hepatocellular carcinoma (HCC) |
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ZBTB7A was found to enhance the migration and invasion of HCC by increasing MEF2D expression |
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transcription factor ZBTB7A is important for haematopoietic lineage fate decisions and for regulation of glycolysis |
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is a potential modulator of breast cancer metastasis |
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functions as a tumor suppressor in gastric cancer cells |
CELLULAR PROCESS
|
nucleotide, transcription, regulation
|
| cell organization/biogenesis
|
small molecule
|
metal binding,
|
| ion Zn2+ binding |
protein
| binding to BCL6 |
|
bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation |
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interacting with RB1 through four GC-rich promoter elements (FREs) located at bp –308 to –188 of the RB promoter region (potently represses transcription of the RB1 gene, a tumor suppressor gene important in cell cycle arrest) ((Jeon 2008) |
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directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM |
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EPAS1 plays an indispensible role in SP1 transcription factor-mediated ZBTB7A induction, and participated in tumor cell survival and proliferation |
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is a new partner of SMAD4 and plays a negative role in TGFB1 pathway |
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ZBTB7A directly binds to the promoter and transcriptionally represses the expression of MCAM, establishing ZBTB7A as a bona fide transcriptional repressor of MCAM |
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ZBTB7A transcription factor occupies fetal HBG1 genes and maintains the nucleosome density necessary for HBG1 gene silencing in adults |
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ZBTB7A, ZBTB7B unlike in conventional T cells, functions in Tregs are not mediated by their repression of the transcription factor RUNX3 |
induced by
| induced during the early phases of preadipocyte differentiation where it may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation |
Other
| upregulated during early phase of liver regeneration |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
aberrantly, in breast, lung, colon, prostate and bladder carcinomas | tumoral
| germinal mutation
|  
|  
|  
|
in acute myeloid leukaemia with t(8;21) translocation | tumoral
|  
|  
|  
| loss of function
|
loss-of-function mutation in ZBTB7A is a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| is a potential prognostic biomarker for breast cancer | Therapy target
| attractive therapeutic target for the treatment of many types of cancer |
| |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
aberrantly, in breast, lung, colon, prostate and bladder carcinomas | tumoral
| germinal mutation
|  
|  
|  
|
in acute myeloid leukaemia with t(8;21) translocation | tumoral
|  
|  
|  
| loss of function
|
loss-of-function mutation in ZBTB7A is a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
| is a potential prognostic biomarker for breast cancer | Therapy target
| attractive therapeutic target for the treatment of many types of cancer |
| |