Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DDX6 contributors: mct - updated : 08-10-2019
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
HGNC id 2747
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp-Glu-Ala-Asp/His)
  • an helicase ATP-binding domain, an ATPase/helicase motif essential for viral replication
  • a C terminal RNA helicase domain, and C-terminal RecA-like domain
    • HOMOLOGY
    interspecies homolog to Drosophila oocyte specific helicase ME31
    homolog to murine Ddx6 (97,7pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX6/DHH1 subfamily
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text
  • in spermatogenic cells, localizes to both the nucleus and cytoplasm
    • basic FUNCTION
  • shuttling protein involved in nuclear assembly of stored mRNP particles
  • in the process of mRNA degradation, may play a role in mRNA decapping
  • possibly involved in the replication of hepatitis C virus genomes in hepatocytes and in tumourigenesis of hepatocellular carcinomas
  • DEAD-box RNA helicase with ATP-dependent RNA-unwinding activity
  • it is possible that DDX6 may be an important driver of the aggregation process within P bodies (was shown to be essential for P-body formation in human cells)
  • is required for efficient genome packaging of foamy virus, a spumaretrovirus
  • located at the 5prime extremity of mRNA can then recruit the decapping complex, thus coupling translational repression and mRNA degradation
  • reduction of DDX6 under prolonged hypoxia activates expression of proangiogenic VEGFA that is critical in fast growing tissues during normal development and in pathologic processes
  • is present in nuage and non-nuage structures as well as nuclei, suggesting that DDX6 has diverse functions in spermatogenic cells
  • having versatile functions in mRNA metabolism, which characterize them as important post-transcriptional regulators of gene expression
  • DDX6 is necessary and sufficient for neuronal differentiation and that it functions in cooperation with TRIM32
  • conserved DEAD-box protein (DBP) that plays central roles in cytoplasmic RNA regulation, including processing body (P-body) assembly, mRNA decapping, and translational repression
  • has a variety of functions such as translation initiation, pre-mRNA splicing, and ribosome assembly
  • parental mRNA clearance is a prerequisite for cellular reprogramming and that DDX6 plays a central role in this process
  • is an essential component of membrane-less organelles called processing bodies (PBs)
  • plays a key role in adult progenitors where it controls the balance between self-renewal and differentiation in a context-dependent manner
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of P-bodies and stress granules, representing cellular structures of mRNA triage
  • EIF4E/EIF4ENIF1 complex is present in granules with the processing body proteins LSM1 and DDX6, and disruption of this complex causes premature and enhanced neurogenesis and neural precursor depletion
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATXN2
  • interacts with argonaute proteins, EIF2C1, EIF2C2
  • interacting with EDC3 (DDX6 C-terminal RecA-like domain bound to a highly conserved FDF sequence motif in the decapping activator EDC3)
  • general translational repressor DDX6 may cooperate with ZFP36 to regulate AU-rich elements (AREs)-mRNA translation
  • ATXN2L associates with known interaction partners of ATXN2, the RNA helicase DDX6 and the poly(A)-binding protein, and with ATXN2 itself
  • hypoxia-induced DDX6 reduction positively affects proangiogenic VEGFA expression
  • CNOT1 modulates the conformation of DDX6 and stimulates ATPase activity
  • can remodel and release nuclear DMPK messenger ribonucleoprotein foci, leading to normalization of pathogenic alternative splicing events
  • DDX6 binds to a conserved CNOT1 subdomain in a manner resembling the interaction of the translation initiation factor EIF4A with EIF4G
  • CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway
  • TRIM32 associates with proteins involved in neurogenesis and RNA-related processes, such as the RNA helicase DDX6, which has been implicated in microRNA regulation
  • interacts with the CNOT complex and functions in concert with several post-transcriptional regulators, including EDC3, and EIF4ENIF1
  • EIF4ENIF1 through conserved CUP-homology domain (CHD) interacts directly with DDX6 in both the presence and absence of the central MIF4G domain of CNOT1
  • DDX6-EIF4ENIF1 interaction mediates translational repression and P-body assembly
  • DDX6 protein acted as an RNA-binding protein for ERBB2 and FGFR2 mRNAs and positively regulated their post-transcriptional processes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IDDF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in intestine, colon, rectum adenocarcinomas
    tumoral   translocation    
    translocated in B-cell lymphoma, RCK gene (RC-K8 cell line) target of the translocation t(11;14)(q23;q32)
    constitutional     --over  
    in hepatitis C virus-related chronic hepatitis
    constitutional     --low  
    under hypoxia contributes to the activation of VEGFA expression and promotes its proangiogenic function
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS