| basic FUNCTION
| shuttling protein involved in nuclear assembly of stored mRNP particles |
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in the process of mRNA degradation, may play a role in mRNA decapping |
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possibly involved in the replication of hepatitis C virus genomes in hepatocytes and in tumourigenesis of hepatocellular carcinomas |
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DEAD-box RNA helicase with ATP-dependent RNA-unwinding activity |
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it is possible that DDX6 may be an important driver of the aggregation process within P bodies (was shown to be essential for P-body formation in human cells)  |
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is required for efficient genome packaging of foamy virus, a spumaretrovirus |
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located at the 5prime extremity of mRNA can then recruit the decapping complex, thus coupling translational repression and mRNA degradation |
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reduction of DDX6 under prolonged hypoxia activates expression of proangiogenic VEGFA that is critical in fast growing tissues during normal development and in pathologic processes |
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is present in nuage and non-nuage structures as well as nuclei, suggesting that DDX6 has diverse functions in spermatogenic cells |
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having versatile functions in mRNA metabolism, which characterize them as important post-transcriptional regulators of gene expression |
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DDX6 is necessary and sufficient for neuronal differentiation and that it functions in cooperation with TRIM32 |
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conserved DEAD-box protein (DBP) that plays central roles in cytoplasmic RNA regulation, including processing body (P-body) assembly, mRNA decapping, and translational repression |
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has a variety of functions such as translation initiation, pre-mRNA splicing, and ribosome assembly |
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parental mRNA clearance is a prerequisite for cellular reprogramming and that DDX6 plays a central role in this process |
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is an essential component of membrane-less organelles called processing bodies (PBs) |
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plays a key role in adult progenitors where it controls the balance between self-renewal and differentiation in a context-dependent manner |
