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FLASH GENE

Symbol

CD27

contributors: SGE/npt - updated : 23-06-2016

HGNC name	CD27 molecule
HGNC id	11922

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p13      Physical location : 6.554.050 - 6.560.883
Synonym name	CD27 antigen
	CD27L receptor
	T cell activation antigen CD27
	cell differentiation antigen CD27, identified by monoclonal antibodies H235, O-323, M-T271, OKT18
	tumor necrosis factor receptor superfamily, member 7
Synonym symbol(s)	T14, S152, Tp55, TNFRSF7, MGC20393

DNA

TYPE	functioning gene
STRUCTURE	6.83 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CD27 6 - 1320 26.9 260 - Van Lier (1987)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune lymph node       highly   spleen       highly Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
	a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
	a small cytoplasmic domain without catalytic activity and lacking a DEATH domain

conjugated

GlycoP , PhosphoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to rattus CD27 (68.8pc)

Homologene

FAMILY

tumor necrosis factor receptor (TNF) superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane protein type 1

basic FUNCTION	playing a key role in regulating B-cell activation and immunoglobulin synthesis
	receptor required for generation and long-term maintenance of T cell immunity
	transducing signals that lead to the activation of NF-kappaB and MAPK8/JNK
	potential role for ZAP70 dependent signaling in CD27 induction, implicating CD27 in cell-cell interactions with the lymphoid tissue microenvironment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to SIVA1 and involved in apoptosis
	binding to its ligand CD70
	interacting with TRAF2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS