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FLASH GENE
Symbol CD27 contributors: SGE/npt - updated : 23-06-2016
HGNC name CD27 molecule
HGNC id 11922
Location 12p13      Physical location : 6.554.050 - 6.560.883
Synonym name
  • CD27 antigen
  • CD27L receptor
  • T cell activation antigen CD27
  • cell differentiation antigen CD27, identified by monoclonal antibodies H235, O-323, M-T271, OKT18
  • tumor necrosis factor receptor superfamily, member 7
  • Synonym symbol(s) T14, S152, Tp55, TNFRSF7, MGC20393
    DNA
    TYPE functioning gene
    STRUCTURE 6.83 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1320 26.9 260 - Van Lier (1987)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats typical for the TNFR superfamily
  • a preligand assembly domain (PLAD) in CRD1 mediating ligand-independent receptor assembly and signaling
  • a small cytoplasmic domain without catalytic activity and lacking a DEATH domain
  • conjugated GlycoP , PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus CD27 (68.8pc)
    Homologene
    FAMILY
  • tumor necrosis factor receptor (TNF) superfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • playing a key role in regulating B-cell activation and immunoglobulin synthesis
  • receptor required for generation and long-term maintenance of T cell immunity
  • transducing signals that lead to the activation of NF-kappaB and MAPK8/JNK
  • potential role for ZAP70 dependent signaling in CD27 induction, implicating CD27 in cell-cell interactions with the lymphoid tissue microenvironment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SIVA1 and involved in apoptosis
  • binding to its ligand CD70
  • interacting with TRAF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS