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FLASH GENE

Symbol

GPR55

contributors: mct - updated : 18-08-2011

HGNC name	G protein-coupled receptor 55
HGNC id	4511

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.90 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005683 2 - 3828 - 319 - 2007 17765871

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune lymph node       highly Homo sapiens   spleen       highly Homo sapiens   thymus       highly Homo sapiens nervous brain basal nuclei putamen     Nervous brain basal nuclei caudate nucleus   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphoblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

intraspecies

homolog to P2RY5,GPR23,GPR35,CCR4

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

signaling , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	receptor for cannabinoids
	role of GPR55 in bone physiology by regulating osteoclast number and function
	GPR55 and its endogenous ligand SLC7A7 play essential roles in the homoeostatic responses to stress signals in several mammalian tissues and cells including certain types of immune cells
	potential role as a receptor for the lysophospholipid lysophosphatidylinositol (LPI, SLC7A7)
	role of SLC7A7 and its receptor GPR55 in cancer cells in activating an autocrine loop that regulates cell proliferation
	orphan G protein-coupled receptor that may be engaged by some lipid ligands such as lysophosphatidylinositol and cannabinoid-type compounds

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

DDHD1-SLC7A7-GPR55 axis may be involved in functions in the brain (

INTERACTION

DNA

RNA

small molecule

protein	specific and functional receptor for lysophosphatidylinositol (SLC7A7)
	binds a subset of CB1 and CB2 ligands and has been proposed as a cannabinoid receptor

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in several prostate and ovarian cancer cell lines, both at the mRNA and at the protein level (it has a critical role in regulating proliferation and anchorage-independent growth)

Susceptibility

to anorexia nervosa

Variant & Polymorphism other	low-functioning Val195 allele of GPR55 appears to be a risk factor for anorexia nervosa

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     potential therapeutic target miscelleaneous pain   manipulation of GPR55 may have therapeutic potential in the treatment of both inflammatory and neuropathic pain

ANIMAL & CELL MODELS