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FLASH GENE
Symbol MCM3AP contributors: mct - updated : 22-02-2017
HGNC name MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
HGNC id 6946
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS)
  • a coiled coil structure
  • four LXXLL motifs typical of nuclear transcription activato
  • C terminal 721AA identical to map 89
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm3AP (minichromosome maintenance mutant)
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in the nuclear localization of MCM3
  • involved in regulation of cell cycle progression and DNA replication of germinal center B cells
  • plays a certain important role in the maturation of immunoglobulin or selection of B cells in germinal centers during the immune response to T cell-dependent antigens
  • nuclear export factor, involved in chromatin modification at rearranged immunoglobulin variable loci, and its activity requires a histone acetyltransferase domain
  • promote likely B-cell maturation by nuclear targeting of activation-induced cytidine deaminase (AID) and to control AID-dependent hyperrecombination
  • protein involved in the export of certain messenger RNAs from the nucleus to the cytoplasm
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is required to recruit ENY2 to nuclear pore complexes (NPCs), but ENY2 is not necessary to recruit MCM3AP
  • interacts with the transcription stalling protein SUPT5H and facilitates RNA Pol-II recruitment to immunoglobulin variable regions
  • MCM3AP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AICDA targeting (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PNRIID
    Susceptibility
    Variant & Polymorphism
    Candidate gene is likely associated with hypokalemic periodic paralyses (PPs)
    Marker
    Therapy target
    ANIMAL & CELL MODELS