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FLASH GENE

Symbol

MCM3AP

contributors: mct - updated : 22-02-2017

HGNC name	MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
HGNC id	6946

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003906 28 - 6403 NP_003897 - 1980 - 2019 31241196

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine thyroid       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal (NLS)
	a coiled coil structure
	four LXXLL motifs typical of nuclear transcription activato
	C terminal 721AA identical to map 89

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae replication Mcm3AP (minichromosome maintenance mutant)

Homologene

FAMILY

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
	intracellular,nuclear envelope

basic FUNCTION	involved in the nuclear localization of MCM3
	involved in regulation of cell cycle progression and DNA replication of germinal center B cells
	plays a certain important role in the maturation of immunoglobulin or selection of B cells in germinal centers during the immune response to T cell-dependent antigens
	nuclear export factor, involved in chromatin modification at rearranged immunoglobulin variable loci, and its activity requires a histone acetyltransferase domain
	promote likely B-cell maturation by nuclear targeting of activation-induced cytidine deaminase (AID) and to control AID-dependent hyperrecombination
	protein involved in the export of certain messenger RNAs from the nucleus to the cytoplasm

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	is required to recruit ENY2 to nuclear pore complexes (NPCs), but ENY2 is not necessary to recruit MCM3AP
	interacts with the transcription stalling protein SUPT5H and facilitates RNA Pol-II recruitment to immunoglobulin variable regions
	MCM3AP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AICDA targeting (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PNRIID

Susceptibility

Variant & Polymorphism

Candidate gene	is likely associated with hypokalemic periodic paralyses (PPs)
Marker
Therapy target

ANIMAL & CELL MODELS