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FLASH GENE
Symbol MCM3AP contributors: mct - updated : 22-02-2017
HGNC name MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
HGNC id 6946
Location 21q22.3      Physical location : 47.655.047 - 47.705.236
Genatlas name germinal center-associated nuclear protein
Synonym name mRNA for MCM3 import factor
Synonym symbol(s) MAP80, KIAA0572, GANP, FLJ44336, FLJ45306
DNA
TYPE like-sequence
STRUCTURE 50.00 kb     28 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrinethyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS)
  • a coiled coil structure
  • four LXXLL motifs typical of nuclear transcription activato
  • C terminal 721AA identical to map 89
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm3AP (minichromosome maintenance mutant)
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the nuclear localization of MCM3
  • involved in regulation of cell cycle progression and DNA replication of germinal center B cells
  • plays a certain important role in the maturation of immunoglobulin or selection of B cells in germinal centers during the immune response to T cell-dependent antigens
  • nuclear export factor, involved in chromatin modification at rearranged immunoglobulin variable loci, and its activity requires a histone acetyltransferase domain
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is required to recruit ENY2 to nuclear pore complexes (NPCs), but ENY2 is not necessary to recruit MCM3AP
  • interacts with the transcription stalling protein SUPT5H and facilitates RNA Pol-II recruitment to immunoglobulin variable regions
  • MCM3AP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AICDA targeting (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS