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| extracellular fibronectin matrix assembly by VHL-/- mouse embryos and mouse embryo fibroblasts (MEFs)was grossly impaired ( | |
loss of DVhl in Drosophila resulted in an ventral midline defect ( |
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deletion of the Von Hippel-Lindau gene (Vhlh) from intrinsic glomerular cells of mice is sufficient to initiate a necrotizing crescentic glomerulonephritis and the clinical features that accompany rapidly progressive glomerulonephritis ( |
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murine embryonic depletion of Vhlh within the pancreatic epithelium causes postnatal lethality due to severe hypoglycemia |
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mice homozygous for the R200W mutation developed polycythemia ( |
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Vhlh-deficient mice exhibited diminished glucose-stimulated changes in cytoplasmic Ca(2+) concentration, electrical activity, and insulin secretion, which culminate in impaired systemic glucose tolerance ( |
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Vhl(2B/2B) mice displayed mid-gestational embryonic lethality, whereas adult Vhl(2B/+) mice exhibited susceptibility to carcinogen-promoted renal neoplasia ( |
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pVHL-deficient RCC 786-O cells were multinucleated and polyploid ( |