protein
| HDAC5, HDAC7, NCOR1, TBL1X |
|
repressing STAT5A, STAT5B dependent transcription |
|
mediates the HDAC4 binding to BACH2, and HDAC4 facilitates the retention of BACH2 in the foci |
|
functional interaction between NCOR2 and FOXP1 is required for cardiac growth and regulation of macrophage differentiation |
|
interaction with PIN1 (interaction requires the WW domain of PIN1 and SMRT phosphorylation, and regulates SMRT protein stability, thereby affecting SMRT-dependent transcriptional repression) |
|
TBL1X interacts with both NCOR2 and GPS2 |
|
CAMK2A down-regulated the protein stability of NCOR2 through proteasomal degradation |
|
WNT5A inhibited the physical association between RBPJ and NCOR2 suggesting that WNT5A induced CAMK2A activation plays a critical role in the endogenous RBPJ-NCOR2 binding |
|
kinase activity of CAMK2A plays a crucial role in the proteasomal degradation of NCOR2 |
|
regulatory cascade containing PPARG and TWIST1 that controlled the expression of GPS2 and NCOR2 in human adipocytes |
|
MAP2K1 interacts with the nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptor (NCOR2) |
|
DEAF1 transcription regulation activity is mediated through interactions with cofactors such as NCOR1 and NCOR2 |
|
is responsible for basal repression of PPM1D, a phosphatase that de-phosphorylates and inactivates CHEK2, thus affecting a feedback loop responsible for licensing the correct timing of CHEK2 activation and the proper execution of the DNA repair process |
|
interaction with NCOR2 is essential for deacetylase-independent function of HDAC3 |
|
target for the ubiquitously expressed protein kinase CSNK2A1, which is known to phosphorylate a wide variety of substrates |
|
(HDAC3)-dependent transcriptional corepressor |
|
TP53 bound to the NCOR2 deacetylase activation domain (DAD), which mediates HDAC3 binding and activation, and HDAC3 could attenuate TP53 binding to the DAD region of NCOR2 |
|
NCOR1 and NCOR2 directly bind to transcription factors and nucleate the formation of stable complexes that include HDAC3, transducin b-like protein 1/TBL1-related protein 1, and GPS2 |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
significantly reduced in obese adipose tissue, inversely correlated to inflammatory status | tumoral
|  
|  
| --low
|  
|
observed in leukemias, lymphomas, and androgen-resistant prostate carcinomas | |