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FLASH GENE

Symbol

BCL10

contributors: mct - updated : 14-10-2016

HGNC name	B-cell CLL/lymphoma 10
HGNC id	989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Lymphoid/Immune lymph node       highly Reproductive female system breast mammary gland   highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal caspase recruitement domain (CARD), and a 13-AAs region downstream of the CARD domain is responsible for interacting with the immunoglobulin-like domains of MALT1
	a C terminal region rich in serine and threonine residues

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Bcl10

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	perinuclear structures when bound to CARD11

basic FUNCTION	positive regulator of lymphocyte proliferation that specifically connects antigen receptor signaling in B and T cells to NFKB activation
	positive regulator of cell apoptosis
	essential mediator of LPA (lysophosphatidic)-induced NF-kappaB activation
	potential transcriptional activator that interacts with general transcription factor GTF2B
	key signaling component mediating NF-B activation induced by G protein-coupled receptors in nonlymphoid cells
	forms a complex with MALT1 to activate the IKK complex through ubiquitination of the IKK/NEMO subunit of the IKK complex in antigen receptor signaling pathways
	CARD10 and BCL10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion
	CARD11/BCL10/MALT1 (CBM) signalosome mediates antigen receptor-induced NFKB1 signaling to regulate multiple lymphocyte functions
	CARD11, BCL10, and MALT1, that have complex 5'UTRs and encode proteins with short half-lives, are involved in BCR signaling

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	promoting apoptosis and suppressing malignant transformation in vitro

PATHWAY

metabolism

signaling

signal transduction

pathway of NF-kappa B activation, CARD10-BCL10-MALT1 signaling pathway mediates NF-B activation in response to antigen receptor stimulation in lymphocytes

a component	forming a ternary complex with CARD10, MALT1
	CARD11-BCL10-MALT1 (CBM) complex connects T-cell receptor (TCR) signalling to the canonical IkappaB kinase (IKK)/NF (nuclear factor)-kappaB pathway
	CARD9-BCL10-MALT1 pathway activated by SYK
	CARD10-BCL10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis

INTERACTION

DNA

RNA

small molecule

protein	CARD11
	death domain of MALT1 and the CARD of BCL10 also contribute to BCL10-MALT1 interactions
	IL2-independent STAT5B target gene
	interacting with CALM1 (CALM1 regulates T cell responses to antigens by binding to BCL10, thereby modulating its interaction with CARD11 and subsequent activation of NF-kappaB)
	interacting with CAMK2G (phosphorylates the CARD domain of BCL10, which regulates the interactions within the important CARD11, BCL10, MALT1 signalling complex)
	CARD11 serves as a scaffold for BCL10, MALT1 and other effector proteins and regulates various signaling pathways related to the immune response
	interaction mode between CARD11 CARD and BCL10 CARD based on a structure-based modeling study
	ATM-dependent phosphorylation of BCL10 promotes its interaction with and presentation of UBE2N to RNF8, and RNF8-mediated ubiquitination of BCL10 enhances binding of BCL10 and UBE2N to RNF168
	novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists
	AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NFKB1 signaling upon T cell activation
	CARD14 recruits BCL10 and MALT1 to form the CARD-BCL10-MALT1 complex, which modulates NFKB1 and MAPK signalling pathway

cell & other

viral E10

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MALTL , IMD37

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     t (1;14)(p22;q32) as uncommon but recurrent events in MALT lymphoma tumoral   deletion     involving 1, 10, 17 chromosome in Sezary syndrome and chromosome instability tumoral fusion       an IGH-BCL2-fusion with t(1;14)(p22;q32), in MALT lymphoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Bcl 10-/- mice (Ruland 01)