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FLASH GENE

Symbol

GCM2

contributors: mct/shn - updated : 30-11-2016

HGNC name	glial cells missing homolog 2 (Drosophila)
HGNC id	4198

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FIHP , HRPT4

Susceptibility

to primary hyperparathyroidism (PHPT)

Variant & Polymorphism SNP	higher frequency of GCM2 282D in PHPT and enhanced transcriptional activity of this variant supports the notion that it could contribute causally to parathyroid tumorigenesis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular bone   is a possible target for pharmacologic manipulation of PTH excess or deficiency

ANIMAL & CELL MODELS

	Gcm2-deficient mice are viable and fertile but lack parathyroid glands and exhibit a biological hypoparathyroidism (
	Loss of Gcm1 gene result in the impaired induction of mouse neural stem cells (
	in mice, homozygous disruption of Gcm2 by conventional gene targeting results in parathyroid aplasia and hypoparathyroidism