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FLASH GENE
Symbol RANBP1 contributors: mct/npt - updated : 05-03-2010
HGNC name RAN binding protein 1
HGNC id 9847
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a region sharing homogeneity with cAMP dependent protein kinase
  • a RanBD1 domaain
  • a nuclear export signal sharing homoloigy with the NES of the inhibitor of cAMP dependent protein kinase
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Ranbp1
    homolog to C.elegans k05f1.9
    Homologene
    FAMILY
  • Ras-related small nuclear protein (RANBP1) family
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • inhibiting GTP dissociation
  • increasing GTP hydrolysis by the RAN GTPase activating protein (RANGAP1)
  • regulates centrosome cohesion during mitosis (Di Fiore 2003)
  • regulator of RCC1 (regulator of chromatin condesation 1)
  • has an established role in spindle assembly and in mitotic progression (Tedeschi 2007)
  • its activity is required for the proper localization of specific factors that regulate microtubule function; loss of this activity contributes to the generation of aneuploidy in a microtubule-dependent manner (Tedeschi 2007)
  • contributes to regulate the function of the mitotic apparatus (Rensen 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a trimeric complex with RANGAP1,RANBP7 or RANBP8
  • forming a trimeric complex with Ran-GDP and importin-beta, and RANBP1 restores the GDP nucleotide exchange by importin-beta by forming a tetrameric complex with importin-beta, Ran, and importin-alpha (Lonhienne 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ran complexed with GTP specifically (not GDP)
  • interacts with importin-beta, but this interaction is weaker than the Ran-GTP/importin-beta interaction (Lonhienne 2009)
  • interacting with RANBP1 and RANGAP1 (phosphorylation of RANGAP1 stabilizes its interaction with RAN and RANBP1) (Takeda 2005)
  • binds RAN and regulates its interaction with effectors (Rensen 2009)
  • interacting with RAN and RANGAP1 (phosphorylation of RANGAP1 stabilizes its interaction with RAN and RANBP1) (Takeda 2005)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    sensitizes cancer cells to taxol in a caspase-3-dependent manner, and can modulate the outcome of mitotic microtubule-targeting therapeutic protocols (Rensen 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene velocardiofacial syndrome/DiGeorge syndrome candidate gene (Maynard 2002)
    Marker
    Therapy target
    ANIMAL & CELL MODELS