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FLASH GENE

Symbol

GRAP

contributors: mct - updated : 04-04-2023

HGNC name	GRB2-related adaptor protein
HGNC id	4562

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	30.72 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

between SMS-REPM and SMS-REPP

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006613 5 - 1988 NP_006604 25.2 217 - 2019 30610177 NM_001330148 4 - 1819 NP_001317077 - 205 - 2019 30610177

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

arrangement of SH3-SH2 domain as in GRB2

mono polymer

complex

HOMOLOGY

interspecies

homolog to C.elegans c14f5.5

Homologene

FAMILY

GRB2/sem-5/DRK family

CATEGORY

adaptor , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	Grb2-related adaptor protein 1
	coupling tyrosine kinase to the RAS pathway
	SH3/SH2 adaptor protein
	potential novel role for GRAP in TGF-beta-induced tubule injury in diabetic kidney disease
	GRB2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

cell to cell signaling

a component

forming a stable complex with the BSR-ABL oncoprotein

INTERACTION

DNA

RNA

small molecule

protein	interacting with cKIT
	EPOR binding
	ras guanine nucleotide exchange factor SOS1
	BCR-ABL oncoprotein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DFNB114

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

GRAP was up-regulated in kidney tubules from diabetic mice and fibrotic kidneys from diabetic patients